Maduo Project
This is a research study in Gaborone, Botswana looking to estimate current rates for curable STIs in pregnancy, including correlates of infection and frequency of mother-to-child transmission; compare neonatal outcomes between children born to tested and treated vs. syndromic-managed pregnant mothers; and investigate immunological and inflammatory predictors of vertical transmission of STIs in pregnancy.
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Study title: The diagnosis and treatment of Chlamydia trachomatis and Neisseria gonorrhoeae in pregnant women to prevent adverse neonatal consequences
Award number: R21HD100821
Funding source: National Institute of Child Health & Human Development
Philani Ndiphile Trial
This is a clinical research study in Eastern Cape, South Africa looking to generate evidence for the optimal STI diagnostic strategy in pregnancy that best mitigates adverse birth outcomes, evaluate the cost-effectiveness of this optimal strategy compared to alternatives and investigate potential microbiological predictors of/contributors to the persistence of STIs.
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Study title: Clinical study of STI screening to prevent adverse birth and newborn outcomes
Award number: R01AI49339
Funding source: National Institute of Allergy and Infectious Diseases