Maduo Project

This is a research study in Gaborone, Botswana looking to estimate current rates for curable STIs in pregnancy, including correlates of infection and frequency of mother-to-child transmission; compare neonatal outcomes between children born to tested and treated vs. syndromic-managed pregnant mothers; and investigate immunological and inflammatory predictors of vertical transmission of STIs in pregnancy.

Study title: The diagnosis and treatment of Chlamydia trachomatis and Neisseria gonorrhoeae in pregnant women to prevent adverse neonatal consequences                                                                                                                                                    Award number: R21HD100821                                                                                                                                                                                 Funding source: National Institute of Child Health & Human Development

Philani Ndiphile Trial

This is a clinical research study in Eastern Cape, South Africa looking to generate evidence for the optimal STI diagnostic strategy in pregnancy that best mitigates adverse birth outcomes, evaluate the cost-effectiveness of this optimal strategy compared to alternatives and investigate potential microbiological predictors of/contributors to the persistence of STIs.

Study title: Clinical study of STI screening to prevent adverse birth and newborn outcomes                                          Award number: R01AI49339.                                                                                                                                                                   Funding source: National Institute of Allergy and Infectious Diseases